Modification of Interleukin-10 with Mannose- 6-Phosphate Groups Yields a Liver-Specific Cytokine with Antifibrotic Activity in Rats

Chemical modification of interleukin-10 with mannose 6-phosphate groups yields a liver-selective cytokine.

Cytokines are considered a promising immunotherapy for chronic diseases, because of their potency and fundamental roles in pathological processes. However, their therapeutic use is limited because of their poor pharmacokinetics and pleiotropic effects in various organs. These problems may be overcome by cell-specific delivery of the cytokine. This approach involves chemical modification of the ...

Dmd#13490 Chemical Modification of Interleukin-10 with Mannose 6-phosphate Groups Yields a Liver-selective Cytokine

Evaluation of Grapefruit Juice in terms of Interleukin 18 Gene Expression in Rats with Fatty Liver and Healthy Rats

Introduction: Interleukin 18 (IL-18) is a member of the cytokine family and an important regulator of inflammatory reactions. Due to the severe and irreversible complications of this disease in the advanced stages, timely treatment, especially with herbal medicines, can be considered an important strategy. This study aimed to investigate the effect of grapefruit extract on the IL-18 gene expres...

THE INHIBITORY EFFECT OF DEHYDROEPIANDROSTERONE ON THE ACTIVITY AND ISOENZYME PATTERNS OF LIVER GLUCOSE 6-PHOSPHATE DEHYDROGENASE DURING DIFFERENT STAGES OF GROWTH

The effect of dehydroepiandrosterone (DHEA) on the activity and isoenzyme patterns of liver glucose 6- phosphate dehydrogenase (G6PD) was investigated in rats during different stages of growth. G6PD activity of mature rats was less than those of the immature (43%) and newborn (35%) animals. DHEA at 10 M) inhibited G6PD activity of the mature , immature and newborn rats by 79%, 39% , and 88%...

Effect of Cyperus Rotundus on Cytokine Gene Expression in Experimental Inflammatory Bowel Disease

Background: The protective effect of the chloroform extract of Cyperus rotundus (CHCR) is attributed to its anti-inflammatory and antioxidant activities. Cytokines, important regulators of inflammation and repair, play a key role in the pathogenesis of inflammatory bowel disease (IBD). Targeting these cytokines can effectively ameliorate the symptoms of IBD. The aim of the present study was to ...